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Product
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Sox2 Antibody
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Cat#
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100-31-02A
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Unit/Weight
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100 μg
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Unit Price
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$343.00
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Species Reactivity
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H, M, R, B, Sh, P, D, Rb
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Tested Application(s)
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IF
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Brief Description
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Rabbit Polyclonal Antibody, RhoB-conjugated Antibody
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Specific Description
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Transcription factor SOX-2 (Sox2) forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Defects in Sox2 are the cause of microphthalmia syndromic type 3 (MCOPS3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. POU5F1/OCT4, Sox2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
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Storage
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Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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