|
Product
|
AQP2 (Ser269) Antibody
|
|
Cat#
|
100-32-82A
|
|
Unit/Weight
|
100 μg
|
|
Unit Price
|
$381.00
|
|
Species Reactivity
|
B, D, M
|
|
Tested Application(s)
|
E, WB
|
|
Brief Description
|
Rabbit Polyclonal Antibody, Phosphospecific Antibody
|
|
Specific Description
|
Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is expressed in the renal collecting tubules. Defects in AQP-2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria). AQP-2 belongs to the MIP/aquaporin (TC1.A.8) family. Serine-269 has been identified as a vasopressin-mediated phosphorylation site on AQP2 and as such has shown to potentiate plasma membrane retention of AQP2.
|
|
Storage
|
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
|
|