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Product
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Connexin-43 (Ser368) Antibody
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Cat#
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100-32-75A
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Unit/Weight
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100 μg
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Unit Price
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$381.00
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Species Reactivity
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B, D, Ck, G, H, M, Zf
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Tested Application(s)
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E, WB
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Brief Description
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Rabbit Polyclonal Antibody, Phosphospecific Antibody
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Specific Description
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Connexin-43 (Gap junction alpha-1 protein, GJA1) forms connexons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Connexin-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Connexons are composed of a hexamer of connexins. Connexin-43 is expressed in the heart and fetal cochlear. Phosphorylation of Ser368 by PKC induces a conformational change of connexin-43 that results in a decrease in gap junction permeability. Defects in connexin-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities.
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Storage
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Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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