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Product
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Gap-43 (Ser41) Antibody
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Cat#
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100-32-58A
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Unit/Weight
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100 μg
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Unit Price
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$381.00
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Species Reactivity
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B, D, Ck, H, M, X, Zf
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Tested Application(s)
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E, WB
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Brief Description
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Rabbit Polyclonal Antibody, Phosphospecific Antibody
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Specific Description
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GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic axonal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC, PIP2, actin, calmodulin, spectrin, palmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.
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Storage
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Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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