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Product
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PAK-1/2/3 (Thr402) Antibody
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Cat#
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100-32-34A
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Unit/Weight
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100 μg
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Unit Price
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$346.00
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Species Reactivity
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B, D, H, M, R
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Tested Application(s)
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E, WB
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Brief Description
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Phosphospecific Antibody, Rabbit Polyclonal Antibody
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Specific Description
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Serine/threonine-protein kinase PAK-1 (PAK-1) is a protein kinase that acts on a variety of targets. PAK-1 is the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. PAK-1 is activated by CDC42 and RAC1, and is involved in dissolution of stress fibers and reorganization of focal complexes. PAK-1 is involved in regulation of microtubule biogenesis through phosphorylation of TBCB. PAK-1 activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Autophosphorylation of Thr402 has been found to be essential for activation of PAK.
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Storage
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Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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