|
Product
|
Phospho-CREB-1 (Ser133) Antibody
|
|
Cat#
|
100-32-30A
|
|
Unit/Weight
|
100 μg
|
|
Unit Price
|
$273.00
|
|
Species Reactivity
|
H, M, R
|
|
Tested Application(s)
|
E, WB, IHC
|
|
Brief Description
|
Rabbit Polyclonal Antibody, Phosphospecific Antibody
|
|
Specific Description
|
The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA, a sequence present in many viral and cellular promoters. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1, ATF-2, ATF-3 and ATF-4. These transcription factors share highly-related COOH terminal leucine zipper dimerization and basic DNA binding but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in certain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recently been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265-kDa nuclear protein designated CBP (CREB-binding protein), which represents a CREB co-activator. Phosphorylation of Ser-133 is key for CREB transcriptional activity.
|
|
Storage
|
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
|
|