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Product
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CD42b (HIP1) Antibody
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Cat#
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100-30-23A
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Unit/Weight
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2 ml
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Unit Price
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$299.00
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Species Reactivity
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H
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Tested Application(s)
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FC
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Brief Description
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Mouse Monoclonal Antibody, PE-conjugated Antibody
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Specific Description
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The CD42b (HIP1) antibody recognizes a heterodimer glycoprotein (GPIbα) that contains an α chain (CD42b, 145 kDa) and a β chain (CD42c, 22 kDa) linked by a disulfide bond forming a noncovalent complex with CD42a (GPIX) and d. CD42b antigen is expressed on platelets and megakaryocytes. The GPIb/IX complex (CD42a-d) serves as a receptor for von Willebrand Factor (vWF) and thrombin, and mediates adhesion of platelets to subendothelium of damaged vascular walls. The absence of the CD42 complex leads to the Bernard-Soulier Syndrome (BSS). The CD42b (HIP1) antibody inhibits the ristocetin-dependent binding of vWF to platelets, ristocetin-induced platelet agglutination, and partially inhibits collagen-induced aggregation.
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Storage
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Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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