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Product
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CD52 (HI186) Antibody
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Cat#
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100-30-19A
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Unit/Weight
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2 ml
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Unit Price
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$299.00
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Species Reactivity
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H
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Tested Application(s)
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FC
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Brief Description
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Mouse Monoclonal Antibody, PE-conjugated Antibody
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Specific Description
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The CD52 (HI186) antibody recognizes a 25-29 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein typically expressed at high levels on thymocytes, lymphocytes, NK cells, monocytes/macrophages. CD52 is expressed at 2% on some granulocytes and epithelial cells of male reproductive tract, and also expressed at variable levels on the majority of lymphoid malignancies, but not on erythrocytes and platelets. A somatic defect in the synthesis of GPI anchors causes a lack of CD52 antigen on cell surface on lymphocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH) . CD52 may be used to diagnose PNH besides CD55 and CD59. All CD52 antibodies are characterized by a strong lytic activity with human complement, irrespective of antibody isotype.
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Storage
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Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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