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Product
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APH1 Antibody
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Cat#
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100-16-02A
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Unit/Weight
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100 μg
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Unit Price
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$311.00
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Species Reactivity
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H, M, R
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Tested Application(s)
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E, WB, IHC
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Brief Description
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Pepmic offers APH1 Antibody product having catalog no is 4003
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Specific Description
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APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gammasecretase complex which cleave the amyloid precursor protein (APP) at what are known as the gammaand gammasites and can lead to the accumulation of the Amyloid beta peptide Abetacleavage product that is associated with Alzheimer’s disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gammasecretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE.
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Storage
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APH1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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