APH1 Antibody

Product   APH1 Antibody Cat#   100-16-01A Unit/Weight   100 μg Unit Price   $266.00 Species Reactivity   H, M Tested Application(s)   E, WB Brief Description   Pepmic provides APH1 Antibody product, APH1 was initially identified as a component of the Notch pathway in C. elegans. Specific Description   APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gammasecretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma and epsilonsites and can lead to the accumulation of the Amyloid betapeptide Abetacleavage product that is associated with Alzheimer’s disease. APH1 exists in at least three distinct isoforms with APH1alpha as the principal isoform present in the gammasecretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE. Storage   APH1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.