|
Product
|
Acetylated Lysine Antibody
|
|
Cat#
|
100-28-17A
|
|
Unit/Weight
|
100 μg
|
|
Unit Price
|
$446.00
|
|
Species Reactivity
|
H, M, R
|
|
Tested Application(s)
|
IF, IHC
|
|
Brief Description
|
FITC-conjugated Antibody, Modification Specific Antibody, Rabbit Polyclonal Antibody
|
|
Specific Description
|
DNA transcription cannot take place unless DNA is unwound from the nucleosomes. The cell unwinds DNA by acetylation of lysine residues of histones. Research has shown that acetylation of non-histone proteins (e.g. transcription factors) and histones are involved in transcription. Histone acetyltransferases (HAT) acetylate the conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) on lysine residues, whereas histone deacetylases (HDAC) remove them. This pan-specific antibody recognizes proteins with acetyllysine residues. This antibody has been utilized for proteomic studies of protein acetylation, immunoaffinity chromatography separation and isolation of acetylated proteins and peptides from protease-digested whole cells.
|
|
Storage
|
Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed 6 months from the date of shipment.
|
|