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Product
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TSLP Receptor Antibody
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Cat#
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100-12-57A
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Unit/Weight
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100 μg
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Unit Price
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$266.00
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Species Reactivity
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M
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Tested Application(s)
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E, WB
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Brief Description
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Mouse thymic stromal lymphopoietin receptor
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Specific Description
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Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.
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Storage
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TSLP Receptor antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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