|
Product
|
TIM-1 Antibody
|
|
Cat#
|
100-12-50A
|
|
Unit/Weight
|
100 μg
|
|
Unit Price
|
$266.00
|
|
Species Reactivity
|
H, M, R
|
|
Tested Application(s)
|
E, WB
|
|
Brief Description
|
(IN) T cell immunoglobulin and mucin domain containing protein 1
|
|
Specific Description
|
The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
|
|
Storage
|
TIM-1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
|
|