Product
|
ORAI1 Antibody
|
Cat#
|
100-12-33A
|
Unit/Weight
|
100 μg
|
Unit Price
|
$311.00
|
Species Reactivity
|
H, M, R
|
Tested Application(s)
|
E, WB, IHC
|
Brief Description
|
(CT) a T cell calcium channel
|
Specific Description
|
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
|
Storage
|
ORAI1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures
|
|