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Product
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ADAP Antibody
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Cat#
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100-12-01A
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Unit/Weight
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100 μg
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Unit Price
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$311.00
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Species Reactivity
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H, M
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Tested Application(s)
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E, WB, ICC
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Brief Description
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Pepmic offers ADAP Antibody product,it also known as The adhesion and degranulation adaptor protein
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Specific Description
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The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
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Storage
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ADAP antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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