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Product
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gp120 Antibody
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Cat#
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100-10-16A
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Unit/Weight
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100 μg
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Unit Price
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$266.00
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Species Reactivity
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V
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Tested Application(s)
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E, WB
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Brief Description
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Pepmic provided gp120 (IN) antibody protect to entry into target cells is directed by the envelope (Env) glycoproteins.
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Specific Description
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Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.
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Storage
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gp120 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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