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Product
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BAD Antibody
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Cat#
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100-2-18A
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Unit/Weight
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100 μg
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Unit Price
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$311.00
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Species Reactivity
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H, M, R
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Tested Application(s)
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E, WB, IHC
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Brief Description
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Bcl-2 family member
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Specific Description
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Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death (reviewed in 1 and 2). Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax (3). Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival (4), whereas JNK-induced phosphorylation promotes the apoptotic role of Bad (5).
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Storage
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BAD antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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