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Product
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Apaf-1 Monoclonal Antibody
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Cat#
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100-2-09A
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Unit/Weight
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100 μg
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Unit Price
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$311.00
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Species Reactivity
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H, M, R
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Tested Application(s)
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E, IHC
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Brief Description
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Pepmic offers Apaf-1 Monoclonal Antibody product, Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3).
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Specific Description
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Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1 (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Apaf1 can also associate with caspase-4 and caspase-8 (4). Apaf1 transcript is ubiquitously expressed in human tissues (1).
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Storage
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Apaf-1 monoclonal antibody can be stored at 4°C, stable for one year.
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