Apaf1 Antibody

Product   Apaf1 Antibody Cat#   100-2-08A Unit/Weight   100 μg Unit Price   $311.00 Species Reactivity   H, M, R Tested Application(s)   E, WB, IHC Brief Description   Pepmic offers Apaf1 Antibody product,Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3). Specific Description   Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1 (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Apaf1 can also associate with caspase-4 and caspase-8 (4). Apaf1 transcript is ubiquitously expressed in human tissues . Storage   Apaf1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.