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Product
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Fas R, Human
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Cat#
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101-25-10B
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Sequence
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QVTDINSKGL ELRKTVTTVE TQNLEGLHHD GQFCHKPCPP
GERKARDCTV NGDEPDCVPC QEGKEYTDKA HFSSKCRRCR
LCDEGHGLEV EINCTRTQNT KCRCKPNFFC NSTVCEHCDP
CTKCEHGIIK ECTLTSNTKC KEEGSRS
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Unit/Weight
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50 μg
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Unit Price
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$218.00
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Description
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Fas Receptor and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
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Molecular Weight
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17~29 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant Human Fas Receptor remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Fas Receptor should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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