|
Product
|
sFASR/TNFRSF6, Human
|
|
Cat#
|
101-25-04B
|
|
Sequence
|
RLSSKSVNAQ VTDINSKGLE LRKTVTTVET QNLEGLHHDG
QFCHKPCPPG ERKARDCTVN GDEPDCVPCQ EGKEYTDKAH FSSKCRRCRL
CDEGHGLEVE INCTRTQNTK CRCKPNFFCN STVCEHCDPC TKCEHGIIKE
CTLTSNTKCK EEGSRSN
|
|
Unit/Weight
|
20 μg
|
|
Unit Price
|
$152.00
|
|
Description
|
Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.
|
|
Molecular Weight
|
Approximately 17.6 kDa, a single non-glycosylated polypeptide chain containing 157 amino acids.
|
|
Purity
|
> 95 % by SDS-PAGE and HPLC analyses.
|
|
Storage
|
This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
|