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Product
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sTRAIL R-2/TNFRSF10B, Human
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Cat#
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101-25-01A
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Sequence
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ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG
RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE
GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES
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Unit/Weight
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10 μg
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Unit Price
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$58.00
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Description
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Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2 (TRAIL-R2) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling.1 The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells.2 TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients.
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Molecular Weight
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Approximately 14.8 kDa, a single non-glycosylated polypeptide chain containing 132 amino acids.
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Purity
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> 97 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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