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Product
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Kallikrein 6, Human
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Cat#
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101-32-146A
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Sequence
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EEQNKLVHGG PCDKTSHPYQ AALYTSGHLL CGGVLIHPLW
VLTAAHCKKP NLQVFLGKHN LRQRESSQEQ SSVVRAVIHP DYDAASHDQD
IMLLRLARPA KLSELIQPLP LERDCSANTT SCHILGWGKT ADGDFPDTIQ
CAYIHLVSRE ECEHAYPGQI TQNMLCAGDE KYGKDSCQGD SGGPLVCGDH
LRGLVSWGNI PCGSKEKPGV YTNVCRYTNW IQKTIQAKHH
HHHHHHHH
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Unit/Weight
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10 μg
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Unit Price
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$138.00
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Description
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Kallikrein 6 (KLK-6) , also known as Zyme, Neurosin, PRSS9, myelencephalon-specific protease (MSP) and protease M, is a trypsin-like serine proteinase. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis, and some have potential as novel cancer and other disease biomarkers. KLK-6 was originally characterized from the brain as an enzyme involved in the degradation of amyloid plaque protein (APP) and was thought to be a beta secretase. KLK-6 was shown to be elevated in the sera of patients with Alzheimer’s disease, Parkinson’s disease and in animal models of multiple sclerosis. Studies indicate KLK-6 may participate in the demyelination processes and progression of CNS inflammatory disease.
Recombinant Human Kallikrein 6 produced in CHO cells is a polypeptide chain containing 238 amino acids. A fully biologically active molecule, rhKLK6 has a molecular mass of 31 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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31 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Recombinant Human Kallikrein 6 remains stable up to 6 months at -20°C to -80°C from date of receipt under sterile conditions. Up to 3 months at -20 °C to -80 °C under sterile conditions after opening. Avoid repeated freeze-thaw cycles.
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