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Product
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Cathepsin L, Human
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Cat#
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101-32-131A
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Sequence
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EAPRSVDWRE KGYVTPVKNQ GQCGSCWAFS ATGALEGQMF
RKTGRLISLS EQNLVDCSGP QGNEGCNGGL MDYAFQYVQD
NGGLDSEESY PYEATEESCK YNPKYSVAND TGFVDIPKQE
KALMKAVATV GPISVAIDAG HESFLFYKEG IYFEPDCSSE
DMDHGVLVVG YGFESTESDN NKYWLVKNSW GEEWGMGGYV
KMAKDRRNHC GIASAASYPT VHHHHHH
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Unit/Weight
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10 μg
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Unit Price
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$138.00
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Description
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Cathepsin L, also known as Aldrichina grahami cysteine proteinase, is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has also been shown to proteolytically inactivate α-1-antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract. Cathepsin L expression has been reported in many organisms including fish, birds and mammals.
Recombinant Human Cathepsin L produced in CHO cells is a polypeptide chain containing 227 amino acids. A fully biologically active molecule, rhCathepsin L has a molecular mass of 40 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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40 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE & HPLC.
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Storage
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Recombinant Human Cathepsin L remains stable up to 6 months at -20°C to -80°C from date of receipt under sterile conditions. Up to 3 months at -20°C to -80 °C under sterile conditions after opening. Avoid repeated freeze-thaw cycles.
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