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Product
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Cathepsin B, Human
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Cat#
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101-32-130A
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Sequence
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RSRPSFHPLS DELVNYVNKR NTTWQAGHNF YNVDMSYLKR
LCGTFLGGPK PPQRVMFTED LKLPASFDAR EQWPQCPTIK
EIRDQGSCGS CWAFGAVEAI SDRICIHTNA HVSVEVSAED
LLTCCGSMCG DGCNGGYPAE AWNFWTRKGL VSGGLYESHV
GCRPYSIPPC EHHVNGSRPP CTGEGDTPKC SKICEPGYSP
TYKQDKHYGY NSYSVSNSEK DIMAEIYKNG PVEGAFSVYS
DFLLYKSGVY QHVTGEMMGG HAIRILGWGV ENGTPYWLVA
NSWNTDWGDN GFFKILRGQD
HCGIESEVVA GIPRTDQYWE KIHHHHHHHH HH
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Unit/Weight
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10 μg
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Unit Price
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$138.00
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Description
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Cathepsin B is an enzymatic protein that is a member of the peptidase (or protease) family. Elevated levels of cathepsin B occur in a wide variety of disease, causing numerous pathologies including cell death, inflammation, and the production of toxic peptides. For example, neuroscience research suggests that cathepsin B plays a role in inducing epilepsy resulting in a significant amount of cell death. Seizure-induced rats treated with a cathepsin B inhibitor exhibited improved neurological scores and learning ability with reduced neuronal cell death.
Recombinant Human Cathepsin B produced in CHO cells is a polypeptide chain containing 332 amino acids. A fully biologically active molecule, rhCathepsin B has a molecular mass of 43 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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43 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by reducing SDS-PAGE.
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Storage
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Recombinant Human Cathepsin B remains stable up to 6 months at -20°C to -80°C from date of receipt under sterile conditions. Up to 3 months at -20°C to -80°C under sterile conditions after opening. Avoid repeated freeze-thaw cycles.
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