|
Product
|
DKK-1, Human
|
|
Cat#
|
101-32-116C
|
|
Sequence
|
TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG
NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC
LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE
ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR
SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL
EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRH
|
|
Unit/Weight
|
1 mg
|
|
Unit Price
|
$2193.00
|
|
Description
|
Dickkopf related protein 1 (DKK1) is a chemokine that belongs to the DKK protein family, which alsoincludes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbatein vitro. DKK1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK1 not only functions as a head inducer during development, but also regulates joint remodeling and bone formation, which indicate sits role in the pathogenesis of rheumatoid arthritis and multiple myeloma.
|
|
Molecular Weight
|
17-22 kDa, observed by reducing SDS-PAGE.
|
|
Purity
|
> 95% as analyzed by SDS-PAGE.
|
|
Storage
|
Lyophilized recombinant human DKK1 (rhDKK1) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhDKK1 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
|
|