|
Product
|
WISP-1, Human
|
|
Cat#
|
101-32-111B
|
|
Sequence
|
TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC
PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD
YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY
NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ
WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP
WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD
IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG
VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC
NLSCRNPNDI FADLESYPDF SEIAN
|
|
Unit/Weight
|
25 μg
|
|
Unit Price
|
$88.00
|
|
Description
|
WISP-1, also known as Wnt-1-inducible-signaling pathway protein 1, CCN4 and Wnt-1-induced secreted protein, is a cysteine-rich heparin-binding Glycoprotein belonging to the CCN protein family. It is expressed in many internal organs, such as the lung, kidney and spleen. WISP-1 binds to BMP-2 and enhances mesenchymal cell proliferation and osteoblastic differentiation. , WISP-1 has also been reported to attenuate p53-mediated apoptosis and inhibit TNF-induced cell death, suggesting it may play a role intumorigenesis.
|
|
Molecular Weight
|
44-46 kDa, observed by reducing SDS-PAGE.
|
|
Purity
|
> 95% as analyzed by SDS-PAGE.
|
|
Storage
|
Lyophilized recombinant human WISP-1 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human WISP-1 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
|
|