H7N9 (A/Hangzhou/1/2013), Hemagglutinin
Product   H7N9 (A/Hangzhou/1/2013), Hemagglutinin
Cat#   101-32-101A
Sequence   DKICLGHHAV SNGTKVNTLT ERGVEVVNAT ETVERTNIPR ICSKGKRTVD LGQCGLLGTI TGPPQCDQFL EFSADLIIER REGSDVCYPG KFVNEEALRQ ILRESGGIDK EAMGFTYSGI RTNGATSACR RSGSSFYAEM KWLLSNTDNA AFPQMTKSYK NTRKSPALIV WGIHHSVSTA EQTKLYGSGN KLVTVGSSNY QQSFVPSPGA RPQVNGISGR IDFHWLMLNP NDTVTFSFNG AFIAPDRASF LRGKSMGIQS GVQVDANCEG DCYHSGGTII SNLPFQNIDS RAVGKCPRYV KQRSLLLATG MKNVPEIPKG RGLFGAIAGF IENGWEGLID GWYGFRHQNA QGEGTAADYK STQSAIDQIT GKLNRLIEKT NQQFELIDNE FNEVEKQIGN VINWTRDSIT EVWSYNAELL VAMENQHTID LADSEMDKLY ERVKRQLREN AEEDGTGCFE IFHKCDDDCM ASIRNNTYDH SKYREEAMQN RIQIDPVKLS SGYKDVHHHH HHHH
Unit/Weight   10 μg
Unit Price   $32.00
Description   Influenza hemagglutinin (HA) is a glycoprotein found on the surface of the influenzavirus. It is responsible for binding the virus to cells with sialic acid on their membranes, such as cells in the upper respiratory tract or erythrocytes. It is also responsible for the fusion of the viral envelope with the endosome membrane after the pH has been reduced. The name "hemagglutinin" comes from the protein's ability to cause red blood cells (erythrocytes) to clump together in vitro. HA has two functions. First, it allows the recognition of target vertebrate cells, accomplished through binding to these cells' sialic acid-containing receptors. Second, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. H7N9 is a subtype of influenza virus A and the most common cause of influenza in humans. Recombinant Influenza A H7N9 (A/Hangzhou/1/2013(H7N9)) Hemagglutinin with his-tag produced in Sf9 Cells is a single, non-glycosylated polypeptide chain containing 514 amino acids. A fully biologically active molecule, HA-H7N9 has a molecular mass of ~60 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
Molecular Weight   ~60 kDa, observed by reducing SDS-PAGE.
Purity   >95% by SDS-PAGE and HPLC analyses.
Storage   Lyophilized recombinant Influenza A H7N9 (A/Hangzhou/1/2013(H7N9)) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, HA-H7N9 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.