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Product
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Betacellulin, Mouse(HEK 293-expressed)
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Cat#
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101-32-92B
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Sequence
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DGNTTRTPET NGSLCGAPGE NCTGTTPRQK VKTHFSRCPK
QYKHYCIHGR CRFVVDEQTP SCICEKGYFG ARCERVDLFY
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Unit/Weight
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50 μg
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Unit Price
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$152.00
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Description
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Betacellulin, also known as BTC, belongs to the EGF family of growth factors. It is expressed in many tissues, such as kidney, pancreas and small intestine. Betacellulin is initially synthesized as a membrane-bound precursor containing multiple EGF-like domains in its extracellular region, and is released from the membrane by proteolytic cleavage. BTC is the ligand for EGFR/ErbB receptor tyrosine kinases, and plays a role in cell growth and differentiation. BTC has been reported to promote beta cell growth and differentiation in the pancreas. Pancreas-specific expression of this gene may induce islet neogenesis and remediate hyperglycemia in type I diabetes.
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Molecular Weight
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19-24 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE and HPLC.
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Storage
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Lyophilized recombinant murine Betacellulin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Murine Betacellulin should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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