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Product
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NOV, Human
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Cat#
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101-32-86B
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Sequence
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TQRCPPQCPG RCPATPPTCA PGVRAVLDGC SCCLVCARQR
GESCSDLEPC DESSGLYCDR SADPSNQTGI CTAVEGDNCV
FDGVIYRSGE KFQPSCKFQC TCRDGQIGCV PRCQLDVLLP
EPNCPAPRKV EVPGECCEKW ICGPDEEDSL GGLTLAAYRP
EATLGVEVSD SSVNCIEQTT EWTACSKSCG MGFSTRVTNR
NRQCEMLKQT RLCMVRPCEQ EPEQPTDKKG KKCLRTKKSL
KAIHLQFKNC TSLHTYKPRF CGVCSDGRCC TPHNTKTIQA
EFQCSPGQIV KKPVMVIGTC TCHTNCPKNN EAFLQELELK
TTRGKM
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Unit/Weight
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50 μg
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Unit Price
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$188.00
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Description
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Nephroblastoma Overexpressed Gene Protein (NOV), also known as CCN3, IGFBP9 and NOVH, is one of the CCN family of secreted proteins. It is expressed in bone marrow, thymic cells and nephroblastoma. NOV signals through integrin receptors, NOTCH1 and fibulin 1c to regulate multiple cellular activities, such as cell adhesion, migration, proliferation and differentiation. The reported functions of NOV are diverse. It has been reported to play a role in angiogenesis and stem cell self-renewal. It has also been implicated in osteogenic differentiation, embryo development and cancer pathogenesis.
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Molecular Weight
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20-50 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE and HPLC.
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Storage
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Lyophilized recombinant Human NOV remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human NOV should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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