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Product
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Adiponectin, Human(CHO-expressed)
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Cat#
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101-32-77B
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Sequence
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ETTTQGPGVL LPLPKGACTG WMAGIPGHPG HNGAPGRDGR
DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ
GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN
QQNHYDGSTG KFHCNIPGLY YFAYHITVYM KDVKVSLFKK
DKAMLFTYDQ YQENNVDQAS GSVLLHLEVG DQVWLQVYGE
GERNGLYADN DNDSTFTGFL LYHDTN
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Unit/Weight
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50 μg
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Unit Price
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$188.00
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Description
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Adiponectin is an important adipokine involved in the control of fat metabolism and insulin sensitivity. It is synthesized exclusively by adipocytes and secreted into plasma. It antagonizes THF-alpha by negatively regulating its expression. It also inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin can form low molecular weight complexes (LMW), middle molecular weight complexes (MMW) and higher molecular weight complexes (HMW). These bind to various growth factors, such as HBEGF, PDGFB and FGF2, and play a role in cell growth, angiogenesis and tissue remodeling.
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Molecular Weight
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25~28 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE and HPLC.
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Storage
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Lyophilized recombinant Human Adiponectin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human Adiponectinshould be stable up to 1 week at 4°C or up to 2 months at -20°C.
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