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Product
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UBE2K/E2-25K, His, Human
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Cat#
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101-32-29A
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Sequence
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MHHHHHHAMA NIAVQRIKRE FKEVLKSEET SKNQIKVDLV
DENFTELRGE IAGPPDTPYE GGRYQLEIKI PETYPFNPPK
VRFITKIWHP NISSVTGAIC LDILKDQWAA AMTLRTVLLS
LQALLAAAEP DDPQDAVVAN QYKQNPEMFK QTARLWAHVY
AGAPVSSPEY TKKIENLCAM GFDRNAVIVA LSSKSWDVET
ATELLLSN
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Unit/Weight
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10 μg
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Unit Price
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$152.00
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Description
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Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene. The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.
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Molecular Weight
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Approximately 23.4 kDa, a single non-glycosylated polypeptide chain containing 200 amino acids (a.a.) of human UBE2K and 8 a.a. vector sequence including 6 ?His tag at N-terminus.
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Purity
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>95% by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
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