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Product
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BX/SVTLE, Reptile
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Cat#
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101-32-23A
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Sequence
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VIGGDECDIN EHPFLAFMYY SPRYFCGMTL INQEWVLTAA
HCNRRFMRIH LGKHAGSVAN YDEVVRYPKE KFICPNKKKN VITDKDIMLI
RLDRPVKNSE HIAPLSLPSN PPSVGSVCRI MGWGAITTSE DTYPDVPHCA
NINLFNNTVC REAYNGLPAK TLCAGVLQGG IDTCGGDSGG PLICNGQFQG
ILSWGSDPCA EPRKPAFYTK VFDYLPWIQS IIAGNKTAT
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Unit/Weight
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10 μg
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Unit Price
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$58.00
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Description
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Batroxobin is a serine protease derived from the venom of Bothrops atrox. This thrombin-like proteolytic enzyme splits the 16 Arg-17 Gly bond in the A (alpha)-chain of fibrinogen, releasing fibrinopeptide A and leading to the clot formation through aggregation of formed of fibrin I monomer or Des-AA-monomer. In contrast to other anti-coagulants, it does not affect the functions of platelets. Hence, Batroxobin is used to determine fibrinogen in plasma, to measure a 'batroxobin clotting time' as a heparin-insensitive parallel to the thrombin time, to investigate dysfibrinogenemia, and to test the contractile system of platelets.
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Molecular Weight
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A single, glycosylated, polypeptide chain containing 231 amino acids, and having a molecular mass of approximately 28,000~33,000.
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Purity
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>97% by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
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