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Product
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Kallikrein-1, His, Human
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Cat#
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101-32-21A
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Sequence
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MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CEQHSQPWQA
ALYHFSTFQC GGILVHRQWV LTAAHCISDN YQLWLGRHNL
FDDENTAQFV HVSESFPHPG FNMSLLENHT RQADEDYSHD
LMLLRLTEPA DTITDAVKVV ELPTEEPEVG STCLASGWGS
IEPENFSFPD DLQCVDLKIL PNDECKKAHV QKVTDFMLCV
GHLEGGKDTC VGDSGGPLMC DGVLQGVTSW GYVPCGTPNK
PSVAVRVLSY VKWIEDTIAE NSHHHHHH
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Unit/Weight
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20 μg
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Unit Price
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$58.00
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Description
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Kallikreins are members of a highly conserved serine proteases that are involved in the post-translational modification of many polypeptides, and plays a role in diverse physiological processes. Fifteen kallikreins who seen coding genes are located in a cluster on chromosome 19 have been reported, and growing evidence suggests that many kallikreins are implicated in carcinogens is and some have potential as novel cancer and other disease biomakers. Human kallikrein1(KLK1), also known as tissue kallikrein, is functionally conserved in its capacity to cleave the low molecular weight kininogen to release the vasoactive peptide, Lys-bradykinin which plays a role in regulating vasodilation, blood pressure reduction, smooth muscle relaxation and contraction, pain induction and inflammation.
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Molecular Weight
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Approximately 29.7 kDa, a single non-glycosylated polypeptide chain containing 268 amino acids with 6 ?His at C-terminus.
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Purity
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>95% by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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