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Product
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Endostatin, Human
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Cat#
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101-32-03A
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Sequence
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AHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA
VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL
FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV
WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG
QSAASCHHAY IVLCIENSFM TASK
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Unit/Weight
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20 μg
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Unit Price
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$32.00
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Description
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Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
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Purity
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Greater than 97% by SDS-PAGE
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Storage
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The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20°C. For the first use, reconstitute in water, aliquot and store at -20°C to avoid multiple freeze-thaws.
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