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Product
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NT-4, Mouse
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Cat#
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101-30-25B
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Sequence
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MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE
VLGEVPAAGG SPLRQYFFET RCKAESAGEG GPGVGGGGCR
GVDRRHWLSE CKAKQSYVRA LTADSQGRVG WRWIRIDTAC
VCTLLSRTGR A
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Unit/Weight
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50 μg
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Unit Price
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$268.00
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Description
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Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals . In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NFκB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer’s.
Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E. coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0kDaanalyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
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Molecular Weight
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14.0 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% by SDS-PAGEanalysis.
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Storage
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Lyophilized recombinant mouse Neurotrophin-4 (rmNT-4) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmNT-4 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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