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Product
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GDNF, Mouse
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Cat#
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101-30-23B
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Sequence
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MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR
GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY
DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV
YHILRKHSAK RCGCI
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Unit/Weight
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25 μg
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Unit Price
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$168.00
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Description
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Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson’s Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption.
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Molecular Weight
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17-22 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE and HPLC.
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Storage
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Lyophilized recombinant murine GDNF remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Murine GDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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