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Product
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GDNF, Human
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Cat#
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101-30-06C
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Sequence
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RGQRGKNRGC VLTAIHLNVT DLGLGYETKE ELIFRYCSGS
CDAAETTYDK ILKNLSRNRR LVSDKVGQAC CRPIAFDDDL
SFLDDNLVYH ILRKHSAKRC GCI
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Unit/Weight
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1 mg
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Unit Price
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$2093.00
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Description
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Glial cell line-derived neurotrophic factor (G-DNF) is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems. G-DNF has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons and motor neurons , as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human . GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) .
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Molecular Weight
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30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE and HPLC.
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Storage
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Lyophilized recombinant human Glial cell line-derived neurotrophic factor (G-DNF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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