Product
|
GDNF, Human
|
Cat#
|
101-30-06B
|
Sequence
|
RGQRGKNRGC VLTAIHLNVT DLGLGYETKE ELIFRYCSGS
CDAAETTYDK ILKNLSRNRR LVSDKVGQAC CRPIAFDDDL
SFLDDNLVYH ILRKHSAKRC GCI
|
Unit/Weight
|
50 μg
|
Unit Price
|
$258.00
|
Description
|
Glial cell line-derived neurotrophic factor (G-DNF) is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems. G-DNF has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons and motor neurons , as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human . GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) .
|
Molecular Weight
|
30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.
|
Purity
|
> 95% as analyzed by SDS-PAGE and HPLC.
|
Storage
|
Lyophilized recombinant human Glial cell line-derived neurotrophic factor (G-DNF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
|
|