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Product
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IGF-BP-4, His, Human
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Cat#
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101-22-12A
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Sequence
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DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL
GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM
ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK
HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA
LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG
QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFREHHH
HHH
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Unit/Weight
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10 μg
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Unit Price
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$42.00
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Description
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Insulin-like growth factor-binding protein 4 (IGF-BP-4), also known as IBP-4, is a secreted glycoprotein belonging to the IGFBP family. IGF-BP-4 is produced by osteoblasts, epidermis, ovarian follicles and other tissues. It binds both insulin-like growth factor (IGF) I and II, and it circulates in the plasma in both glycosylated and non-glycosylated forms. IGF-BP-4 prolongs the half-life of the IGFs and has been shown to inhibit or stimulate the growth-promoting effects of the IGFs. Pregnancy Associated Plasma Protein A (PAPP-A) proteolytically cleaves IGF-BP-4 and reduces its affinity to bind IGFs, and thus serves as an important regulator of IGF-BP-4 function.
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Molecular Weight
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30-35 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant human IGF-BP-4 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human IGF-BP-4, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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