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Product
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Exendin-4
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Cat#
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101-29-05A
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Sequence
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HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS
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Unit/Weight
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100 μg
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Unit Price
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$152.00
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Description
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Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ß-cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA squence encoding the 39 amino acid of Exendin-4.
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Molecular Weight
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Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.
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Purity
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>96% by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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