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Product
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GH, Human
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Cat#
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101-29-04A
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Sequence
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FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ
KYSFLQNPQTSLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV
QFLRSVFANSLVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK
QTYSKFDTNSHNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG
F
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Unit/Weight
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100 μg
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Unit Price
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$128.00
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Description
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Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones-GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin and leptin. The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified.
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Molecular Weight
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Approximately 22 kDa, a single non-glycosylated polypeptide chain containing 191 amino acids
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Purity
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>96% by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable for several weeks at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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