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Product
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Human ICAM-1
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Cat#
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101-6-04A
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Sequence
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His-Tag sequence not included: QTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKK ELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVE LAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPA EVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPAT PPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGN DSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVIL TKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGR SFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTP MCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVT REVTVNVLSPREYEIV
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Unit/Weight
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0.01 mg
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Unit Price
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$228.00
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Description
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Intracellular adhesion molecules (ICAM proteins) are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM-1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. ICAM-1 acts as a cellular receptor for rhinovirus and also interacts with human herpes virus 8 MIR2 protein. Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria. Recombinant ICAM-1 comprises a 455 amino acid fragment (28-483) corresponding to the mature extracellular domain of the ICAM-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
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Molecular Weight
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59.97 kDa
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Purity
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Purity > 95% as determined by reducing and non-reducing SDS-PAGE, Bradford assay, Western blot and ELISA
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Storage
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Store at -20°C. Product is guaranteed one year from the date of shipment.
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