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Product
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M-CSF, Mouse
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Cat#
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101-21-48B
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Sequence
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MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD
QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER
LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN
FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP
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Unit/Weight
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50 μg
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Unit Price
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$268.00
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Description
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Macrophage Colony Stimulating Factor (M-CSF) ,also known as CSF1,is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells.M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity.M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation.
Recombinant mouse Macrophage Colony Stimulating Factor (M-CSF) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 156 amino acids each. A fully biologically active molecule, rmM-CSF has a molecular mass of 30 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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30 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant Mouse Macrophage Colony Stimulating Factor(M-CSF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Mouse M-CSF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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