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Product
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Flt-3L, His, Mouse
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Cat#
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101-20-06A
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Sequence
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GTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ
DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI
HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI
GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR
PRHHHHHH
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Unit/Weight
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10 μg
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Unit Price
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$88.00
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Description
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Flt3L, also known as Fms-related tyrosine kinase 3 ligand and SL cytokine, is a single-pass type I membrane protein. It is expressed by stromal cells and T cells. Flt3L signals through tyrosine kinase receptor Flt3/Flk2 to stimulate the proliferation of early hematopoietic progenitor cells. It synergizes with other growth factors, such as GM-CSF, IL-3 and CSF, to promote the differentiation of both myeloid and lymphoid cells. Alternative splicing and proteolytic cleavage of membrane-bound Flt3L generates a soluble extracellular domain (ECD) isoform with full biological activity.
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Molecular Weight
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24-30 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant murine Flt3L, His remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, murine Flt3L, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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