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Product
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FGF-basic, Bovine
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Cat#
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101-19-98B
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Sequence
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PALPEDGGSG AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV
DGVREKSDPH IKLQLQAEER GVVSIKGVCA NRYLAMKEDG
RLLASKCVTD ECFFFERLES NNYNTYRSRK YSSWYVALKR
TGQYKLGPKT GPGQKAILFL PMSAKS
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Unit/Weight
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50 μg
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Unit Price
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$78.00
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Description
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Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the β trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including cardiomycotes, fibroblasts, and vascular cells. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic can be tumorigenic due to its role in angiogenesis and blood vessel remodeling. The angiogenic effects of FGF-basic can produce beneficial cardioprotection during acute heart injury.
Recombinant bovine Fibroblast Growth Factor-basic (rbFGF-basic) produced in E. coli is a single non-glycosylated polypeptide chain containing 146 amino acids. A fully biologically active molecule, rbFGF-basic has a molecular mass of 16.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
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Molecular Weight
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16.4 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% by SDS-PAGE analysis.
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Storage
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Lyophilized recombinant bovine Fibroblast Growth Factor-basic (rbFGF-basic) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rbFGF-basic remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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