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Product
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FGF-21, His, Human
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Cat#
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101-19-95C
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Sequence
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HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT
VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG
ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG
NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV
GSSDPLSMVG PSQGRSPSYA SHHHHHH
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Unit/Weight
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1 mg
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Unit Price
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$1493.00
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Description
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FGF-21, also known as fibroblast growth factor-21 and FGFL, is a secreted growth factor belonging to theheparin-binding growth factor family. It is produced by hepatocytes in response to fatty acid stimulation. FGF-21 couples with its co-factor beta-Klotho to signal through FGFR1c and FGFR4. Signal transduction results in insulin-independent uptake of glucose by adipocytes. Clinical administration of FGF-21 induces energy expenditure, fat utilization and lipid excretion.
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Molecular Weight
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23-25kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant human FGF-21 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human FGF-21, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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