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Product
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FGF-8a, Human
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Cat#
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101-19-86C
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Sequence
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MQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR
INAMAEDGDP FAKLIVETDT FGSRVRVRGA ETGLYICMNK
KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA
FTRKGRPRKG SKTRQHQREV HFMKRLPRGH HTTEQSLRFE
FLNYPPFTRS LRGSQRTWAP EPR
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Unit/Weight
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1 mg
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Unit Price
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$1493.00
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Description
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Fibroblast Growth Factor 8a (FGF-8a) is a cytokine belonging to the heparin-binding FGF family, which has at least 23 members. FGF-8 has 8 different isoforms, named FGF-8a through FGF-8h. Different FGF-8 isoforms have different affinities to the receptors, and thus participate in different signaling cascade pathways. FGF-8 has very widespread expression during embryonic development, and is an organizer and inducer for gastrulation, somitogenesis, morphogenesis, and limb induction. However, FGF-8 is also a potential oncogene: in normal adult cells, FGF-8 has very low expression, but FGF-8 is highly expressed in cancer cells of breast, prostate, and ovarian tumors. FGF-8 promotes tumor angiogenesis by increasing neovascularization, and induces osteoblastic differentiation.
Recombinant human Fibroblast Growth Factor 8a (rhFGF-8a) produced inE. coli is a single non-glycosylated polypeptide chain containing 183 amino acids. A fully biologically active molecule, rhFGF-8a has a molecular mass of 21.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
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Molecular Weight
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21.3 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% by SDS-PAGE analysis.
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Storage
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Lyophilized recombinant human Fibroblast Growth Factor 8a (rhFGF-8a) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-8a remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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