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Product
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FGF-9, Mouse
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Cat#
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101-19-71A
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Sequence
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MPLGEVGSYF GVQDAVPFGN VPVLPVDSPV LLNDHLGQSE
AGGLPRGPAV TDLDHLKGIL RRRQLYCRTG FHLEIFPNGT
IQGTRKDHSR FGILEFISIA VGLVSIRGVD SGLYLGMNEK
GELYGSEKLT QECVFREQFE ENWYNTYSSN LYKHVDTGRR
YYVALNKDGT PREGTRTKRH QKFTHFLPRP VDPDKVPELY
KDILSQS
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Unit/Weight
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10 μg
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Unit Price
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$78.00
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Description
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Fibroblast Growth Factor-9 (FGF-9) is a pleiotropic cytokine and belongs to the heparin-binding FGF family. Like other members in the family, FGF-9 resembles a β-trefoil structure. FGF-9 undergoes reversible dimerization, a common characteristic shared by its subfamily members, FGF-16 and FGF-20. The mutations involved in the homodimerization also affect the affinity for heparin, binding to FGF receptors, and biological activity. In vivo, FGF-9 is expressed in limb buds, the developing skeleton, and in the intestines during late stage embryogenesis. FGF-9 is essential for the development of heart, lung, kidney, cecum, and testes; and the reduction of FGF-9 level leads to premature differentiation. FGF-9 also works along with Bone Morphogenetic Protein-7 (BMP-7) to promote the survival of nephron progenitors.
Recombinant mouse Fibroblast Growth Factor (rmFGF-9) produced in E. coli is a single non-glycosylated polypeptide chain containing 207 amino acids. A fully biologically active molecule, rmFGF-9 has a molecular mass of 23.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
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Molecular Weight
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23.4 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE and HPLC.
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Storage
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Lyophilized recombinant mouse Fibroblast Growth Factor (rmFGF-9) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmFGF-9 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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