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Product
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FGF-18, Mouse
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Cat#
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101-19-56C
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Sequence
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EENVDFRIHV ENQTRARDDV SRKQLRLYQL YSRTSGKHIQ
VLGRRISARG EDGDKYAQLL VETDTFGSQV RIKGKETEFY
LCMNRKGKLV GKPDGTSKEC VFIEKVLENN YTALMSAKYS
GWYVGFTKKG RPRKGPKTRE NQQDVHFMKR YPKGQAELQK
PFKYTTVTKR SR
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Unit/Weight
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1 mg
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Unit Price
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$1493.00
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Description
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Fibroblast Growth Factor 18 (FGF-18) is a pleiotropic cytokine belonging to the heparin-binding FGF family, which has 23 different members. Structurally, FGF-18 is closely related to FGF-8 and FGF-17. Like other FGFs, FGF-18 can bind to different FGF receptors in vivo. FGF-18 is expressed in various tissues and has multiple functions: during long bone growth, FGF-18 is expressed in perichondrium and developing joints, and regulates bone formation by inhibiting chondrocyte proliferation and differentiation; FGF-18 knock-out mice survive embryonic development, but exhibit skeletal abnormalities and die in the early neonatal period. FGF-18 also induces ectopic cartilage formation in the lung, and alters the morphology of the pulmonary mesenchyma.
Recombinant mouse Fibroblast Growth Factor 18 (rmFGF-18) produced in E. coli is a single non-glycosylated polypeptide chain containing of 172 amino acids. A fully biologically active molecule, rmFGF-18 has a molecular mass of 20.1 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
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Molecular Weight
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20.1 kDa, observed by non-reducing SDS-PAGE.
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Purity
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> 95% by SDS-PAGE and HPLC analyses.
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Storage
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Lyophilized recombinant mouse Fibroblast Growth Factor 18 (rmFGF-18) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmFGF-18 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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